Genetically distinct subsets within ANCA-associated vasculitis.

ABSTRACT:

Background

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.

Methods

A genomewide association study was performed in a discovery cohort of 1233 U.K. patients with ANCA-associated vasculitis and 5884 controls and was replicated in 1454 Northern European case patients and 1666 controls. Quality control, population stratification, and statistical analyses were performed according to standard criteria.

Results

We found both major-hi

SUBMITTER: Lyons PA 

PROVIDER: S-EPMC3773907 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature