Heterogeneity of amygdala response in major depressive disorder: the impact of lifetime subthreshold mania.

ABSTRACT:

Background

Patients with major depressive disorder (MDD) present with highly heterogeneous symptom profiles. We aimed to examine whether individual differences in amygdala activity to emotionally salient stimuli were related to heterogeneity in lifetime levels of depressive and subthreshold manic symptoms among adults with MDD.

Method

We compared age- and gender-matched adults with MDD (n = 26) with healthy controls (HC, n = 28). While undergoing functional magnetic resonance imaging, participants performed an implicit emotional faces task: they labeled a color flash superimposed upon initially neutral faces that dynamically morphed into one of four emotions (angry, fearful, sad, happy). Region of interest analyses examined group differences in amygdala activity. For conditi

SUBMITTER: Fournier JC 

PROVIDER: S-EPMC3773940 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature