Comparison of natamycin and voriconazole for the treatment of fungal keratitis.

ABSTRACT:

Objective

To conduct a therapeutic exploratory clinical trial comparing clinical outcomes of treatment with topical natamycin vs topical voriconazole for fungal keratitis.

Methods

The multicenter, double-masked, clinical trial included 120 patients with fungal keratitis at Aravind Eye Hospital in India who were randomized to receive either topical natamycin or topical voriconazole and either had repeated scraping of the epithelium or not.

Main outcome measures

The primary outcome was best spectacle-corrected visual acuity (BSCVA) at 3 months. Other outcomes included scar size, perforations, and a subanalysis of BSCVA at 3 months in patients with an enrollment visual acuity of 20/40 to 20/400.

Results

Compared with those who received natamycin, voriconazole-trea

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC3774126 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature