An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation.

ABSTRACT: During nervous system development, axon branching at nerve terminals is an essential step in the formation of functional connections between neurons and target cells. It is known that target tissues exert control of terminal arborization through secretion of trophic factors. However, whether the in-growing axons themselves produce diffusible cues to instruct target innervation remains unclear. Here, we use conditional mutant mice to show that Wnt5a derived from sympathetic neurons is required for their target innervation in vivo. Conditional deletion of Wnt5a resulted in specific deficits in the extension and arborization of sympathetic fibers in their final target fields, while no defects were observed in the overall tissue patterning, proliferation, migration or differentiation of neuron

SUBMITTER: Ryu YK 

PROVIDER: S-EPMC3774606 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature