Polymorphisms in SELE gene and risk of coal workers' pneumoconiosis in Chinese: a case-control study.

ABSTRACT:

Background

Coal workers' pneumoconiosis (CWP) is characterized by chronic pulmonary inflammation and fibrotic nodular lesions that usually lead to progressive fibrosis. Inflammation is the first step in the development of CWP. E-selectin, an adhesion molecule, is involved in the development of various inflammatory diseases.

Methods

We investigated the association between the functional polymorphisms in SELE and the risk of CWP in Han Chinese population. Three polymorphisms (T1880C/rs5355, T1559C/rs5368, A16089G/rs4786) in SELE were genotyped and analyzed in a case-control study with 697 CWP cases and 694 controls. The genotyping was based on the TaqMan method with the ABI 7900HT Real Time PCR system.

Results

The SELE rs5368 CT genotype was associated with a significan

SUBMITTER: Wang T 

PROVIDER: S-EPMC3774684 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature