Dynamics of response to asynapsis and meiotic silencing in spermatocytes from Robertsonian translocation carriers.

ABSTRACT: Failure of homologous synapsis during meiotic prophase triggers transcriptional repression. Asynapsis of the X and Y chromosomes and their consequent silencing is essential for spermatogenesis. However, asynapsis of portions of autosomes in heterozygous translocation carriers may be detrimental for meiotic progression. In fact, a wide range of phenotypic outcomes from meiotic arrest to normal spermatogenesis have been described and the causes of such a variation remain elusive. To better understand the consequences of asynapsis in male carriers of Robertsonian translocations, we focused on the dynamics of recruitment of markers of asynapsis and meiotic silencing at unsynapsed autosomal trivalents in the spermatocytes of Robertsonian translocation carrier mice. Here we report that the enric

SUBMITTER: Naumova AK 

PROVIDER: S-EPMC3774740 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature