A DOTA-peptide conjugate by copper-free click chemistry.

ABSTRACT: Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.

SUBMITTER: Martin ME 

PROVIDER: S-EPMC3774834 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature