Temporal development of muscle atrophy in murine model of arthritis is related to disease severity.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unknown etiology, affecting mainly the joint but also other tissues. RA patients usually present weakness and muscle atrophy, nonarticular manifestations of the disease. Although causing great impact, the understanding of muscle atrophy, its development, and the mechanisms involved is still very limited. The objective of this study is to evaluate the development of muscle atrophy in skeletal muscle of a murine model of arthritis.

Methods

The experimental murine model of collagen-induced arthritis (CIA) was used. DBA/1J mice were randomly divided into three groups: control (CO, n = 25), sham arthritis (SA, n = 25), and arthritis (CIA, n = 28), analyzed in different time points: 25, 35, and 45 days a

SUBMITTER: Filippin LI 

PROVIDER: S-EPMC3774915 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature