The -159C/T polymorphism in the CD14 gene and tuberculosis risk: a meta-analysis.

ABSTRACT:

Background

The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to tuberculosis, but the results were inconclusive. The present meta-analysis aimed to perform a comprehensive assessment of the literature on the possible association between the -159C/T polymorphism and tuberculosis risk.

Methods

We searched in Pubmed and Embase for studies evaluating the association between the -159C/T gene polymorphism and tuberculosis risk. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software.

Results

A total of seven case-control studies involving 3253 subjects (1,574 tuberculosis cases and 1,679 controls) were included. Combined analysis revealed an obvious association between this polymorphism and tuberculos

SUBMITTER: Wang T 

PROVIDER: S-EPMC3775110 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature