Association of the rs7395662 SNP in the MADD-FOLH1 and several environmental factors with serum lipid levels in the Mulao and Han populations.

ABSTRACT:

Background

The rs7395662 single nucleotide polymorphism (SNP) in the MADD-FOLH1 has been associated with serum lipid traits, but the results are inconsistent in different populations. The present study was undertaken to investigate the association of rs7395662 SNP and several environmental factors with serum lipid levels in the Guangxi Mulao and Han populations.

Method

A total of 721 subjects of Mulao and 727 subjects of Han Chinese were randomly selected from our previous stratified randomized samples. Genotyping of the SNP was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and confirmed by direct sequencing.

Results

Serum apolipoprotein (Apo) B levels were higher in Mulao than in Han (P < 0.01).

SUBMITTER: Huang KK 

PROVIDER: S-EPMC3775112 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature