GUEPARD treat-to-target strategy is significantly more efficacious than ESPOIR routine care in early rheumatoid arthritis according to patient-reported outcomes and physician global estimate.

ABSTRACT:

Objective

To analyse seven RA Core Data Set measures and three indices for their capacity to distinguish treatment results in early RA in the GUEPARD treat-to-target clinical trial vs ESPOIR routine care.

Methods

Post hoc analyses compared 65 GUEPARD and 130 matched control ESPOIR patients over 6 and 12 months for mean changes in measures, relative efficiencies and standardized response means (SRM). Three indices-28-joint disease activity score (DAS28), clinical disease activity index (CDAI) and routine assessment of patient index data (RAPID3)-were compared for mean changes and numbers of patients with high, moderate or low activity or remission using κ values.

Results

Greater improvement was seen for GUEPARD vs ESPOIR, statistically significant for physician and pat

SUBMITTER: Castrejon I 

PROVIDER: S-EPMC3775294 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature