Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3.

ABSTRACT: The multipotent cells of the vertebrate neural crest (NC) arise at the dorsal aspect of the neural tube, then migrate throughout the developing embryo and differentiate into diverse cell types, including the sensory neurons and glia of the dorsal root ganglia (DRG). As multiple cell types are derived from this lineage, it is ideal for examining mechanisms of fate restriction during development. We have isolated a mutant, ouchless, that specifically fails to develop DRG neurons, although other NC derivatives develop normally. This mutation affects the expression of Sorbs3, a scaffold protein known to interact with proteins involved in focal adhesions and several signaling pathways. ouchless mutants share some phenotypic similarities with mutants in ErbB receptors, EGFR homologs that are imp

SUBMITTER: Malmquist SJ 

PROVIDER: S-EPMC3775415 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature