Anti-saccade performance predicts executive function and brain structure in normal elders.

ABSTRACT:

Objective

To assess the neuropsychological and anatomical correlates of anti-saccade (AS) task performance in normal elders.

Background

The AS task correlates with neuropsychological measures of executive function and frontal lobe volume in neurological diseases, but has not been studied in a well-characterized normal elderly population. Because executive dysfunction can indicate an increased risk for cognitive decline in cognitively normal elders, we hypothesized that AS performance might be a sensitive test of age-related processes that impair cognition.

Method

The percentage of correct AS responses was evaluated in 48 normal elderly subjects and associated with neuropsychological test performance using linear regression analysis and gray matter volume measured on m

SUBMITTER: Mirsky JB 

PROVIDER: S-EPMC3775477 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature