Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases.

ABSTRACT:

Objective

To use principal component analyses (PCA) of Pittsburgh compound B (PiB) PET imaging to determine whether the pattern of in vivo β-amyloid (Aβ) in Parkinson disease (PD) with cognitive impairment is similar to the pattern found in symptomatic Alzheimer disease (AD).

Methods

PiB PET scans were obtained from participants with PD with cognitive impairment (n = 53), participants with symptomatic AD (n = 35), and age-matched controls (n = 67). All were assessed using the Clinical Dementia Rating and APOE genotype was determined in 137 participants. PCA was used to (1) determine the PiB binding pattern in AD, (2) determine a possible unique PD pattern, and (3) directly compare the PiB binding patterns in PD and AD groups.

Results

The first 2 principal components (

SUBMITTER: Campbell MC 

PROVIDER: S-EPMC3775684 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature