Contribution of cortical lesion subtypes at 7T MRI to physical and cognitive performance in MS.

ABSTRACT:

Objectives

Evaluate cross-sectionally the contribution of focal cortical lesion (CL) subtypes at ultra-high-field MRI and traditional MRI metrics of brain damage to neurologic disability and cognitive performance in a heterogeneous multiple sclerosis (MS) cohort.

Methods

Thirty-four patients with early or established disease including clinically isolated syndrome, relapsing-remitting MS, and secondary progressive MS were scanned on a human 7-tesla (7T) (Siemens) scanner to acquire fast low-angle shot (FLASH) T2*-weighted images for characterization of white matter and deep gray matter lesion volume, and CL types. Patients also underwent anatomical 3T MRI for cortical thickness estimation, and neuropsychological testing within 1 week of the 7T scan. Twenty-seven patient scans

SUBMITTER: Nielsen AS 

PROVIDER: S-EPMC3775688 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature