An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke.

ABSTRACT:

Objective

We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO.

Methods

Using data from 12 component studies, we used generalized linear mixed models to predict the presence of PFO among patients with CS, and derive a simple index to stratify patients with CS. We estimated the stratum-specific PFO-attributable fraction and stratum-specific stroke/TIA recurrence rates.

Results

Variables associated with a PFO in CS patients included younger age, the presence of a cortical stroke on neuroimaging, and the absence of these factors: diabetes, hypertension, smoking, and prior stroke or TIA. The 10-point Risk of Paradoxical Embolism score is calculated from these v

SUBMITTER: Kent DM 

PROVIDER: S-EPMC3775694 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature