Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine.

ABSTRACT:

Background & aims

Genome-wide association studies have greatly increased our understanding of intestinal disease. However, little is known about how genetic variations result in phenotypic changes. Some polymorphisms have been shown to modulate quantifiable phenotypic traits; these are called quantitative trait loci. Quantitative trait loci that affect levels of gene expression are called expression quantitative trait loci (eQTL), which can provide insight into the biological relevance of data from genome-wide association studies. We performed a comprehensive eQTL scan of intestinal tissue.

Methods

Total RNA was extracted from ileal biopsy specimens and genomic DNA was obtained from whole-blood samples from the same cohort of individuals. Cis- and trans-eQTL analyses were pe

SUBMITTER: Kabakchiev B 

PROVIDER: S-EPMC3775712 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature