Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study.

ABSTRACT: The vast majority of genome-wide association study (GWAS) findings reported to date are from populations with European Ancestry (EA), and it is not yet clear how broadly the genetic associations described will generalize to populations of diverse ancestry. The Population Architecture Using Genomics and Epidemiology (PAGE) study is a consortium of multi-ancestry, population-based studies formed with the objective of refining our understanding of the genetic architecture of common traits emerging from GWAS. In the present analysis of five common diseases and traits, including body mass index, type 2 diabetes, and lipid levels, we compare direction and magnitude of effects for GWAS-identified variants in multiple non-EA populations against EA findings. We demonstrate that, in all populations

SUBMITTER: Carlson CS 

PROVIDER: S-EPMC3775722 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature