Current and former smoking and risk for venous thromboembolism: a systematic review and meta-analysis.

ABSTRACT:

Background

Smoking is a well-established risk factor for atherosclerotic disease, but its role as an independent risk factor for venous thromboembolism (VTE) remains controversial. We conducted a meta-analysis to summarize all published prospective studies and case-control studies to update the risk for VTE in smokers and determine whether a dose-response relationship exists.

Methods and findings

We performed a literature search using MEDLINE (source PubMed, January 1, 1966 to June 15, 2013) and EMBASE (January 1, 1980 to June 15, 2013) with no restrictions. Pooled effect estimates were obtained by using random-effects meta-analysis. Thirty-two observational studies involving 3,966,184 participants and 35,151 VTE events were identified. Compared with never smokers, the overa

SUBMITTER: Cheng YJ 

PROVIDER: S-EPMC3775725 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature