Differential oxidative stress induced by dengue virus in monocytes from human neonates, adult and elderly individuals.

ABSTRACT: Changes in immune response during lifespan of man are well known. These changes involve decreased neonatal and elderly immune response. In addition, it has been shown a relationship between immune and oxidative mechanisms, suggesting that altered immune response could be associated to altered oxidative response. Increased expression of nitric oxide (NO) has been documented in dengue and in monocyte cultures infected with different types of dengue virus. However, there is no information about the age-dependent NO oxidative response in humans infected by dengue virus. In this study, monocyte cultures from neonatal, elderly and adult individuals (n = 10 each group) were infected with different dengue virus types (DENV- 1 to 4) and oxidative/antioxidative responses and apoptosis were measured

SUBMITTER: Valero N 

PROVIDER: S-EPMC3775775 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature