Chronic alcohol induces M2 polarization enhancing pulmonary disease caused by exposure to particulate air pollution.

ABSTRACT:

Background

Chronic alcohol consumption causes persistent oxidative stress in the lung, leading to impaired alveolar macrophage (AM) function and impaired immune responses. AMs play a critical role in protecting the lung from particulate matter (PM) inhalation by removing particulates from the airway and secreting factors which mediate airway repair. We hypothesized AM dysfunction caused by chronic alcohol consumption increases the severity of injury caused by PM inhalation.

Methods

Age- and sex-matched C57BL/6 mice were fed the Lieber-DeCarli liquid diet containing either alcohol or an isocaloric substitution (control diet) for 8 weeks. Mice from both diet groups were exposed to combustion-derived PM (CDPM) for the final 2 weeks. AM number, maturation, and polarization statu

SUBMITTER: Thevenot P 

PROVIDER: S-EPMC3775861 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature