CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.

ABSTRACT:

Background and aims

Gene variants in CHRNA5-A3-B4, which encode for the α5, α3 and β4 nicotinic receptor subunits, are associated with altered smoking behaviors in European Americans. Little is known about CHRNA5-A3-B4 and its association with smoking behaviors and weight in Alaska Native people, which is a population with high prevalence but low levels of tobacco consumption, extensive smokeless tobacco use and high rates of obesity. We investigated CHRNA5-A3-B4 haplotype structure and its association with nicotine intake and obesity in Alaska Native people.

Design, setting and participants

A cross-sectional study of 400 Alaska Native individuals, including 290 tobacco users.

Measurements

CHRNA5-A3-B4 genotype, body weight and tobacco consumption biomarkers such as p

SUBMITTER: Zhu AZ 

PROVIDER: S-EPMC3775934 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature