The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity.

ABSTRACT:

Background

The ankyrin 3 gene (ANK3) produces the ankyrin G protein that plays an integral role in regulating neuronal activity. Previous studies have linked ANK3 to bipolar disorder and schizophrenia. A recent mouse study suggests that ANK3 may regulate behavioral disinhibition and stress reactivity. This led us to hypothesize that ANK3 might also be associated with stress-related psychopathology such as posttraumatic stress disorder (PTSD), as well as disorders of the externalizing spectrum such as antisocial personality disorder and substance-related disorders that are etiologically linked to impulsivity and temperamental disinhibition.

Methods

We examined the possibility of association between ANK3 SNPs and both PTSD and externalizing (defined by a factor score represent

SUBMITTER: Logue MW 

PROVIDER: S-EPMC3775967 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature