Quality of life is significantly impaired in long-term survivors of acute liver failure and particularly in acetaminophen-overdose patients.

ABSTRACT: Functional outcomes for long-term survivors of acute liver failure (ALF) are not well characterized. The aim of this prospective study was to determine health-related quality of life in long-term adult ALF survivors. Acute Liver Failure Study Group registry participants completed the Centers for Disease Control and Prevention Health-Related Quality of Life 14 and Short Form 36 (SF-36) questionnaires at 1- and/or 2-year follow-up study visits. Responses were compared among ALF subgroups and to those for available general US population controls. Among the 282 adult ALF patients, 125 had undergone liver transplantation (LT), whereas 157, including 95 acetaminophen overdose (APAP) patients and 62 non-APAP patients, were spontaneous survivors (SSs). APAP SS patients reported significantly lower

SUBMITTER: Rangnekar AS 

PROVIDER: S-EPMC3775983 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature