Alterations in the rate of binge ethanol consumption: implications for preclinical studies in mice.

ABSTRACT: The rate at which alcohol (ethanol) is consumed has direct impact on its behavioral and subjective effects. For this reason, alterations in the pattern of ethanol consumption as a function of drinking history might be critical to the development and maintenance of alcoholism. Furthermore, because pharmacological interventions aimed at disrupting the motivation to consume ethanol are dependent on the brain/plasma concentrations present when an individual is most likely to engage in consumption of this substance, characterizing temporal drinking patterns might be useful to determine the timing of such treatments. The primary goal of the present study was to evaluate alterations in the timecourse of daily binge (drinking-in-the-dark; DID) ethanol consumption. We gave 14 daily 2 hour DID ethan

SUBMITTER: Linsenbardt DN 

PROVIDER: S-EPMC3775999 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature