Effects of Sirt1 on DNA methylation and expression of genes affected by dietary restriction.

ABSTRACT: Changes in DNA methylation across the life course may contribute to the ageing process. We hypothesised that some effects of dietary restriction to extend lifespan and/or mitigate against features of ageing result from changes in DNA methylation, so we determined if genes that respond to dietary restriction also show age-related changes in DNA methylation. In support of our hypothesis, the intersection of lists of genes compiled from published sources that (1) were differentially expressed in response to dietary restriction and (2) showed altered methylation with increased age was greater than expected. We also hypothesised that some effects of Sirt1, which may play a pivotal role in beneficial effects of dietary restriction, are mediated through DNA methylation. We thus measured effects o

SUBMITTER: Ions LJ 

PROVIDER: S-EPMC3776097 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature