Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake.

ABSTRACT: How interactions of an individual's genetic background and environmental factors, such as dietary salt intake, result in age-associated blood pressure elevation is largely unknown. Lysine-specific demethylase-1 (LSD1) is a histone demethylase that mediates epigenetic regulation and modification of gene transcription. We have shown previously that hypertensive African-American minor allele carriers of the LSD1 single nucleotide polymorphism (rs587168) display blood pressure salt sensitivity. Our goal was to further examine the effects of LSD1 genotype variants on interactions between dietary salt intake, age, and blood pressure. We found that LSD1 single nucleotide polymorphism (rs7548692) predisposes to increasing salt sensitivity during aging in normotensive Caucasian subjects. Using a LS

SUBMITTER: Krug AW 

PROVIDER: S-EPMC3776098 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature