Coenzyme Q(10) supplementation reverses age-related impairments in spatial learning and lowers protein oxidation.

ABSTRACT: Coenzyme Q10 (CoQ) is widely available as a dietary supplement and remains under consideration as a treatment for age-associated neurodegenerative conditions. However, no studies have determined if supplementation, initiated relatively late in life, could have beneficial effects on mild functional impairments associated with normal brain aging. Accordingly, the current study assessed the effect of CoQ intake in older mice for which cognitive and psychomotor impairments were already evident. Separate groups of young (3.5 months) and relatively old mice (17.5 months) were fed a control diet or a diet supplemented with low (0.72 mg/g) or high (2.81 mg/g) concentrations of CoQ for 15 weeks. After 6 weeks, the mice were given tests for spatial learning (Morris water maze), spontaneous locomotor

SUBMITTER: Shetty RA 

PROVIDER: S-EPMC3776107 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature