Hormone replacement therapy and breast cancer: heterogeneous risks by race, weight, and breast density.

ABSTRACT:

Background

Although studies have demonstrated a positive association between hormone replacement therapy (HRT) and breast cancer risk, this association may vary by patient factors.

Methods

We analyzed 1642824 screening mammograms with 9300 breast cancer cases in postmenopausal women aged 45 years or older derived from the Breast Cancer Surveillance Consortium, a longitudinal registry of mammography screening in the United States. Multiple imputation methods were used to accommodate missing data for HRT use (14%) and other covariables. We performed logistic regression to estimate odds ratios (ORs) for breast cancer associated with HRT use within strata of race/ethnicity, age, body mass index (BMI), and breast density, with two-way interaction terms between HRT use and each ke

SUBMITTER: Hou N 

PROVIDER: S-EPMC3776262 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature