Ontology highlight
ABSTRACT:
SUBMITTER: Alexandrov LB
PROVIDER: S-EPMC3776390 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Nature 20130814 7463
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatures of the mutational processes that have been operative. Here we analysed 4,938,362 mutations from 7,042 cancers and extracted more than 20 distinct mutational signatures. Some are present in many cancer types, notably a signature attributed to the APOBEC family of cytidine deaminases, wher ...[more]