New targets for treatment of diabetic nephropathy: what we have learned from animal models.

ABSTRACT:

Purpose of review

There has been an advance in our understanding of the mechanisms of diabetic nephropathy over the past few years and much of that has occurred because of studies in animal models of diabetic nephropathy.

Recent findings

Studies in animal models of diabetic nephropathy, especially in mice, have underlined the multifactorial nature of the pathogenesis of the disease process and the recognition that these models only partly replicate the changes found in human disease. Despite these limitations, recent animal model studies have identified a number of new, specific molecular abnormalities that point to pathways and specific molecules as potential targets for preventive or therapeutic intervention. These specific targets include the diabetic nephropathy related

SUBMITTER: Brosius FC 

PROVIDER: S-EPMC3776427 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature