Comparative effectiveness of 5 treatment strategies for early-stage non-small cell lung cancer in the elderly.

ABSTRACT:

Purpose

The incidence of early-stage non-small cell lung cancer (NSCLC) among older adults is expected to increase because of demographic trends and computed tomography-based screening; yet, optimal treatment in the elderly remains controversial. Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare cohort spanning 2001-2007, we compared survival outcomes associated with 5 strategies used in contemporary practice: lobectomy, sublobar resection, conventional radiation therapy, stereotactic ablative radiation therapy (SABR), and observation.

Methods and materials

Treatment strategy and covariates were determined in 10,923 patients aged ≥ 66 years with stage IA-IB NSCLC. Cox regression, adjusted for patient and tumor factors, compared overall and disease-specifi

SUBMITTER: Shirvani SM 

PROVIDER: S-EPMC3776428 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature