Human placental alkaline phosphatase as a tracking marker for bone marrow mesenchymal stem cells.

ABSTRACT: Currently, adult mesenchymal stem cells (MSCs) are being evaluated for a wide variety of therapeutic approaches. It has been suggested that MSCs possess regenerative properties when implanted or injected into damaged tissue. However, the efficacy of MSCs in several of the proposed treatments is still controversial. To further explore the therapeutic potential of these cells, it is necessary to trace the fate of individual donor or manipulated cells in the host organism. Recent studies from our lab showed that human placental alkaline phosphatase (hPLAP) is a marker with great potential for cell tracking. However, a potential concern related to this marker is its enzymatic activity, which might alter cell behavior and differentiation by hydrolyzing substrates in the extracellular space and

SUBMITTER: Balmayor ER 

PROVIDER: S-EPMC3776624 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature