Meta-analysis of agreement between MRI and pathologic breast tumour size after neoadjuvant chemotherapy.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) has been proposed to guide breast cancer surgery by measuring residual tumour after neoadjuvant chemotherapy. This study-level meta-analysis examines MRI's agreement with pathology, compares MRI with alternative tests and investigates consistency between different measures of agreement.

Methods

A systematic literature search was undertaken. Mean differences (MDs) in tumour size between MRI or comparator tests and pathology were pooled by assuming a fixed effect. Limits of agreement (LOA) were estimated from a pooled variance by assuming equal variance of the differences across studies.

Results

Data were extracted from 19 studies (958 patients). The pooled MD between MRI and pathology from six studies was 0.1 cm (95% LOA: -4.

SUBMITTER: Marinovich ML 

PROVIDER: S-EPMC3776985 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature