Maspin is a marker for early recurrence in primary stage III and IV colorectal cancer.

ABSTRACT:

Background

Little is known about the factors that drive metastasis formation in colorectal cancer (CRC). Here, we set out to identify genes and proteins in patients with colorectal liver metastases that correlate with early disease recurrence. Such factors may predict a propensity for metastasis in earlier stages of CRC.

Methods

Gene expression profiling and proteomics were used to identify differentially expressed genes/proteins in resected liver metastases that recurred within 6 months following liver surgery vs those that did not recur for >24 months. Expression of the identified genes/proteins in stage II (n=243) and III (n=176) tumours was analysed by immunohistochemistry on tissue microarrays. Correlation of protein levels with stage-specific outcome was assessed by un

SUBMITTER: Snoeren N 

PROVIDER: S-EPMC3776998 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature