TNFAIP8 as a predictor of metastasis and a novel prognostic biomarker in patients with epithelial ovarian cancer.

ABSTRACT:

Background

Tumour necrosis factor-α-induced protein 8 (TNFAIP8) has been recently documented in various malignancies, but its role in epithelial ovarian cancer (EOC) remains unknown.

Methods

Tumour necrosis factor-α-induced protein 8 expression was determined by real-time reverse transcription PCR and western blot analysis. Tumour tissues, consisting of serous, mucinous, endometrioid and clear cell histotypes, from 202 EOC patients (International Federation of Gynecologists and Obstetricians I-IV) who underwent primary cytoreduction were collected. Then, we examined the immunohistochemical expression of TNFAIP8 and evaluated its clinical significances.

Results

Tumour necrosis factor-α-induced protein 8 overexpression was significantly associated with high histologic g

SUBMITTER: Liu T 

PROVIDER: S-EPMC3777007 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature