Kinannote, a computer program to identify and classify members of the eukaryotic protein kinase superfamily.

ABSTRACT:

Motivation

Kinases of the eukaryotic protein kinase superfamily are key regulators of most aspects eukaryotic cellular behavior and have provided several drug targets including kinases dysregulated in cancers. The rapid increase in the number of genomic sequences has created an acute need to identify and classify members of this important class of enzymes efficiently and accurately.

Results

Kinannote produces a draft kinome and comparative analyses for a predicted proteome using a single line command, and it is currently the only tool that automatically classifies protein kinases using the controlled vocabulary of Hanks and Hunter [Hanks and Hunter (1995)]. A hidden Markov model in combination with a position-specific scoring matrix is used by Kinannote to identify kinases,

SUBMITTER: Goldberg JM 

PROVIDER: S-EPMC3777111 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature