Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer.

ABSTRACT:

Background

Yes Associated Protein (YAP) has been implicated in the control of organ size by regulating cell proliferation and survival. YAP is a transcriptional coactivator that controls cellular responses through interaction with TEAD transcription factors in the nucleus, while its transcriptional functions are inhibited by phosphorylation-dependent translocation to the cytosol. YAP overexpression has been associated with different types of cancer, such as lung, skin, prostate, ovary and liver cancer. Recently, YAP was linked to E-cadherin-dependent regulation of contact inhibition in breast cancer cells.

Results

In this study we examined YAP protein expression and cellular localization in 237 cases of human invasive breast cancer by immunohistochemistry and related its exp

SUBMITTER: Vlug EJ 

PROVIDER: S-EPMC3777165 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature