Ontology highlight
ABSTRACT:
SUBMITTER: Satoh Y
PROVIDER: S-EPMC3777575 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Immunity 20130620 6
How hematopoietic stem cells (HSCs) produce particular lineages is insufficiently understood. We searched for key factors that direct HSC to lymphopoiesis. Comparing gene expression profiles for HSCs and early lymphoid progenitors revealed that Satb1, a global chromatin regulator, was markedly induced with lymphoid lineage specification. HSCs from Satb1-deficient mice were defective in lymphopoietic activity in culture and failed to reconstitute T lymphopoiesis in wild-type recipients. Furthermo ...[more]