A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum.

ABSTRACT:

Background

Melanoma represents only 4% of all skin cancers, but nearly 80% of skin cancer deaths. This manuscript applies several new measurement technologies with the purpose of elucidating molecular signatures of melanoma aggressiveness.

Purpose

We sought to determine whether low-abundant serum proteins related to apoptotic pathways could be measured and correlated with defined melanoma subtypes. Hydrogel core shell nanoparticles, a new technology capable of selectively entrapping low molecular weight proteins and protecting them from enzymatic degradation, were used to capture candidate serum biomarkers. Biomarker levels were correlated with confocal microscopy, thereby representing a combination of new technologies for in vivo histologic documentation.

Results

Amo

SUBMITTER: Longo C 

PROVIDER: S-EPMC3777620 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature