Resting-state functional connectivity as a marker of disease progression in Parkinson's disease: A longitudinal MEG study.

ABSTRACT: The assessment of resting-state functional connectivity has become an important tool in studying brain disease mechanisms. Here we use magnetoencephalography to longitudinally evaluate functional connectivity changes in relation to clinical measures of disease progression in Parkinson's disease (PD). Using a source-space based approach with detailed anatomical mapping, functional connectivity was assessed for temporal, prefrontal and high order sensory association areas known to show neuropathological changes in early clinical disease stages. At baseline, early stage, untreated PD patients (n = 12) had lower parahippocampal and temporal delta band connectivity and higher temporal alpha1 band connectivity compared to controls. Longitudinal analyses over a 4-year period in a larger patient g

SUBMITTER: Olde Dubbelink KT 

PROVIDER: S-EPMC3777670 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature