Influence of gestational age on death and neurodevelopmental outcome in premature infants with severe intracranial hemorrhage.

ABSTRACT:

Objective

To determine whether death and/or neurodevelopmental impairment (NDI) after severe intracranial hemorrhage (ICH; grade 3 or 4) differs by gestational age (GA) at birth in extremely low birth weight (ELBW) infants.

Study design

Demographic, perinatal and neonatal factors potentially contributing to NDI for ELBW infants (23 to 28 weeks gestation) were obtained retrospectively; outcome data came from the ELBW Follow-up Study. NDI was defined at 18 to 22 months corrected age as moderate/severe cerebral palsy, Bayley Scales of Infant Development II cognitive or motor score <70, and/or blindness or deafness. Characteristics of younger versus older infants with no versus severe ICH associated with death or NDI were compared. Generalized linear mixed models predicted death

SUBMITTER: Goldstein RF 

PROVIDER: S-EPMC3777699 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature