Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study.

ABSTRACT:

Objective

To examine the relation between the type of stress ulcer prophylaxis administered and the risk of postoperative pneumonia in patients undergoing coronary artery bypass grafting.

Design

Retrospective cohort study.

Setting

Premier Research Database.

Participants

21,214 patients undergoing coronary artery bypass graft surgery between 2004 and 2010; 9830 (46.3%) started proton pump inhibitors and 11,384 (53.7%) started H2 receptor antagonists in the immediate postoperative period.

Main outcome measure

Occurrence of postoperative pneumonia, assessed using appropriate diagnostic codes.

Results

Overall, 492 (5.0%) of the 9830 patients receiving a proton pump inhibitor and 487 (4.3%) of the 11,384 patients receiving an H2 receptor antagonist dev

SUBMITTER: Bateman BT 

PROVIDER: S-EPMC3777797 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature