Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study.

ABSTRACT: A comprehensive analysis of the global and regional values of cortical thickness based on 3D magnetic resonance images was performed on 250 relapsing remitting multiple sclerosis (MS) patients who participated in a multi-center, randomized, phase III clinical trial (the CombiRx Trial) and 125 normal controls. The MS cohort was characterized by relatively low clinical disability and short disease duration. An automatic pipeline was developed for identifying images with poor quality and artifacts. The global and regional cortical thicknesses were determined using FreeSurfer software. Our results indicate significant cortical thinning in multiple regions in the MS patient cohort relative to the controls. Both global cortical thinning and regional cortical thinning were more prominent in the l

SUBMITTER: Narayana PA 

PROVIDER: S-EPMC3777814 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature