Vesicular transport of progeny parvovirus particles through ER and Golgi regulates maturation and cytolysis.

ABSTRACT: Progeny particles of non-enveloped lytic parvoviruses were previously shown to be actively transported to the cell periphery through vesicles in a gelsolin-dependent manner. This process involves rearrangement and destruction of actin filaments, while microtubules become protected throughout the infection. Here the focus is on the intracellular egress pathway, as well as its impact on the properties and release of progeny virions. By colocalization with cellular marker proteins and specific modulation of the pathways through over-expression of variant effector genes transduced by recombinant adeno-associated virus vectors, we show that progeny PV particles become engulfed into COPII-vesicles in the endoplasmic reticulum (ER) and are transported through the Golgi to the plasma membrane. Bes

SUBMITTER: Bar S 

PROVIDER: S-EPMC3777860 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature