Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice.

ABSTRACT: An understanding of how pathogens colonize their hosts is crucial for the rational design of vaccines or therapy. While the molecular factors facilitating the invasion and systemic infection by pathogens are a central focus of research in microbiology, the population biological aspects of colonization are still poorly understood. Here, we investigated the early colonization dynamics of Salmonella enterica subspecies 1 serovar Typhimurium (S. Tm) in the streptomycin mouse model for diarrhea. We focused on the first step on the way to systemic infection -- the colonization of the cecal lymph node (cLN) from the gut -- and studied roles of inflammation, dendritic cells and innate immune effectors in the colonization process. To this end, we inoculated mice with mixtures of seven wild type iso

SUBMITTER: Kaiser P 

PROVIDER: S-EPMC3777876 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature