Stress mediators and immune dysfunction in patients with acute cerebrovascular diseases.

ABSTRACT:

Background

Post-stroke immune depression contributes to the development of infections which are major complications after stroke. Previous experimental and clinical studies suggested that humoral stress mediators induce immune dysfunction. However, prospective clinical studies testing this concept are missing and no data exists for other cerebrovascular diseases including intracerebral hemorrhage (ICH) and TIA.

Methods

We performed a prospective clinical study investigating 166 patients with TIA, ischemic and hemorrhagic stroke. We measured a broad panel of stress mediators, leukocyte subpopulations, cytokines and infection markers from hospital admission to day 7 and on follow-up after 2-3 months. Multivariate regression analyses detected independent predictors of immune dy

SUBMITTER: Liesz A 

PROVIDER: S-EPMC3777986 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature