Snail cooperates with KrasG12D to promote pancreatic fibrosis.

ABSTRACT:

Unlabelled

Patients with pancreatic cancer, which is characterized by an extensive collagen-rich fibrotic reaction, often present with metastases. A critical step in cancer metastasis is epithelial-to-mesenchymal transition (EMT), which can be orchestrated by the Snail family of transcription factors. To understand the role of Snail (SNAI1) in pancreatic cancer development, we generated transgenic mice expressing Snail in the pancreas. Because chronic pancreatitis can contribute to pancreatic cancer development, Snail-expressing mice were treated with cerulein to induce pancreatitis. Although significant tissue injury was observed, a minimal difference in pancreatitis was seen between control and Snail-expressing mice. However, because Kras mutation is necessary for tumor developme

SUBMITTER: Shields MA 

PROVIDER: S-EPMC3778055 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature