Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis.

ABSTRACT: Magnetic resonance imaging measures have been proposed as objective markers to study upper motor neuron loss in motor neuron disorders. Cross-sectional studies have identified imaging differences between groups of healthy controls and patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) that correlate with disease severity, but it is not known whether imaging measures change as disease progresses. Additionally, whether imaging measures change in a similar fashion with disease progression in PLS and ALS is unclear. To address these questions, clinical and imaging evaluations were first carried out in a prospective cross-sectional study of 23 ALS and 22 PLS patients with similar motor impairment and 19 age-matched healthy controls. Clinical evaluations consist

SUBMITTER: Kwan JY 

PROVIDER: S-EPMC3778247 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature