Changes in tumour vessel density upon treatment with anti-angiogenic agents: relationship with response and resistance to therapy.

ABSTRACT:

Background

We examine how changes in a surrogate marker of tumour vessel density correlate with response and resistance to anti-angiogenic therapy.

Methods

In metastatic renal cancer patients treated with anti-angiogenic tyrosine kinase inhibitors, arterial phase contrast-enhanced computed tomography was used to simultaneously measure changes in: (a) tumour size, and (b) tumour enhancement (a surrogate marker of tumour vessel density) within individual lesions.

Results

No correlation between baseline tumour enhancement and lesion shrinkage was observed, but a reduction in tumour enhancement on treatment was strongly correlated with reduction in lesion size (r=0.654, P<0.0001). However, close examination of individual metastases revealed different types of response: (1

SUBMITTER: Vasudev NS 

PROVIDER: S-EPMC3778288 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature